World Conference on
Bacteriology and Infectious Diseases

Biography:

Ramesh Gupta is Pro Vice Chancellor, & Professor of chemistry at Nagaland University India. At a age of 23 he received, Doctorate in Chemistry from Lucknow University, India, on Drug Development. Dr. Ramesh Gupta is a Medicinal & Bioorganic Chemist and has worked for several years as visiting professor/Scientist in various Medical schools; Louis pasture University France, University of Arizona USA, Osaka University & Nagoya University Japan, Kyung Hee University, Korea advance institute of science and technology (KAIST) Korea, Ben-Gurion University Israel, Linkoping University Sweden, University of Mons Belgium, University of Western Australia, Sydney ,University of Bergen ,Norway  and some others. Prof Guptas’ research focuses on the Natural & Synthetic Drug Development, role of sulfur amino acids in health care, functional food, nutraceuticals and environmental Biotechnology & gender issues.

Abstract:

The development of antibiotic has created a new world for antimicrobial therapy, but the current rise of antibiotic resistant ‘super bugs’ has put a big question mark on anti microbial research? and compelled to re-look, re-examine the longstanding approaches not only for prevention but also strategies for treatments. There is an urgent need to develop non-antibiotic antimicrobial agents which must have potential to reduce dependence on antibiotics and provide a new front line of defense as well as effective treatment to a wide spectrum of infectious diseases. To hold such views together a new class of compounds have been identified as “Aganocides” which are non-antibiotic in nature, these novel pharmaceuticals has been develop based on molecules  involvement in  host defense and present with in white blood cells and to kill captured microorganisms. N-Halo moiety is the pharmacophore of Aganocides group. Currently perhaps there are no literature records of resistance to this class of molecules N –halo moiety comprises of chloro, bromo and iodo constituents.

Aganocides have potential to replace antibiotics and antiseptics as first order therapy against bacteria, viruses and other pathogens in topical application. In general, antibiotics besides killing bacteria and viruses also damage or destroy human cells. The other line of antiseptic like iodine and alcohol containing solutions has only preventive role and are restricted in their use for infections on tissue surfaces and cavities. however Aganocides are much more effective than these agents and 400-500 times less toxic to animal tissues thus providing higher therapeutic index (the ratio of effective dose to toxic dose) translates directly to patient benefit subsequently higher or similar microbial kill rates. In general Aganocides kill on contact all bacteria, viruses, fungi and protozoa more rapidly in minutes taking very less time as antibiotics takes.

On these lines N-Chloro taurine found in white blood cells has been recognized for treating infectious conjunctivitis, as a natural antiseptic as well as a novel topical antimicrobial agent. The late studies further introduce many others like N-bromo taurine, N, N dichloro taurine and many more.

The conventional therapies for treatment of intra and extra cellular diseases has in existence for many years but several noticeable complication and complexity compelled to update the current strategies and to cope the new emerging challenges of this new millennium the answer lies in new era of Nanotechnology which is perhaps one of the most effective gift of science to mankind. The unique physical and chemical properties of nano particles, particularly their small size and high surface to volume ratio allow this technology to surpass barriers and to gain assess easily to bio-molecules and also to biological systems .In principle manipulation of nano size particles is possible and its size, shape and chemical parameters can be altered in order to facilitate molecular interaction more effectively such development may lead to design engineered vehicles to carry various therapeutic or diagnostic agents which may be potentially useful  for medical application including targeted drug delivery, gene therapy ,cell labeling as well as development of new drug/pharmaceutical/medicine ,and such  agents development through this new technology are designated with new term nano drug/Nano pharmaceuticals/Nano medicine..There are number of taurine containing nano drugs/medicine for immune-modulator to energy provider as well for human skin care.

While Aganocides may provide an ideal therapy for surfaces and cavities throughout the body and could also participate in reducing the contact time, common pathogens have with antibiotics, thus they provide less chance for bacteria to develop resistance, can reverse antibiotics for effectively treating systemic infections their by potentiating their ability to save life with more efficiently. If these Aganocides can join “Umbrella of Nano Technology” perhaps it may constitute much desired and need of hour “our dream antimicrobial agents”.